Buttery et al., Proc Natl Acad Sci U S A 2006
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Our data suggest that alpha1-chimaerin is an activity regulated Rho GTPase regulator that is activated by phospholipase Cbeta coupled cell surface receptors and contributes to pruning of dendritic arbors
Bourdon et al., Methods Enzymol 2006
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This method is readily applied to quantify activation of PLC by receptors and G proteins, and we illustrate here the selective activation of PLC-beta2 by Rac but not by Rho GTPases and the selective activation of PLC-epsilon by Rho but not Rac GTPases