◀ Back to MAPK6
MAPK6 — STAT5A
Text-mined interactions from Literome
Gaur et al., Blood 2001
:
By using avian retroviruses to express wild-type or mutant Mpl on the surfaces of primary megakaryocyte-lineage cells, it was demonstrated that ( 1 ) the 10 membrane-proximal, cytoplasmic amino acids of Mpl are required for TPO induced proliferation ; ( 2 ) Y582F mutation confers a proliferative advantage over wild-type Mpl and imparts a constitutive anti-apoptotic signal ; ( 3 ) truncating the 50 C-terminal Mpl amino acids reduces but does not eliminate TPO induced
mitogen activated protein kinase activation, yet it does not alter the synergistic effect of stem cell factor on TPO induced proliferation ; and ( 4 ) TPO induced proliferation of early, primary megakaryocyte-lineage cells does not
require Stat-5 phosphorylation
Sadowski et al., J Biol Chem 2001
:
Therefore, our results suggest that insulin induction of SOCS-2, and in part SOCS-3 mRNA expression, is mediated by
Stat5 and can be
independent of
mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
Donato et al., Blood 2001
(Leukemia) :
Expression of bcr-abl in interleukin-3 (IL-3)/granulocyte-macrophage colony stimulating factor ( GM-CSF ) -dependent Mo7e cells ( MBA ) resulted in growth factor independence, constitutive
activation of
Stat-5 phosphorylation, engagement of
mitogen activated protein ( MAP ) kinase signals, and increased expression of PTP1B and bcl-x ( L )
Frost et al., Endocrinology 2002
:
The tyrosine kinase inhibitors, genistein, PP1, and AG-490, and the
MAPK kinase inhibitor, PD98059, did not
block Stat3 or
Stat5 phosphorylation
Boer et al., Exp Hematol 2003
:
In addition, enhanced
STAT5 transactivation was
independent of the phosphatidyl inositol 3-kinase and
MAPK ( p42/p44 ) pathways
Maki et al., J Immunol 2008
:
These results demonstrate that MEK1/2 induces TCRgamma germline transcription by phosphorylating STAT5 through IL-7R-FFFF and suggest a potential
role for
MAPK in IL-7R tyrosine independent activation of
STAT5
Williams et al., Blood 2012
(Leukemia) :
This aberrant localization was associated with increased
STAT5 activation but
inhibition of both
MAPK and AKT phosphorylation
Wartmann et al., J Biol Chem 1996
:
Lactogenic hormone activation of
Stat5 and transcription of the beta-casein gene in mammary epithelial cells is
independent of p42 ERK2
mitogen activated protein kinase activity