◀ Back to TNF

ITGA5 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ITGA5-ITGB1 → TNF (increases)
  Evidence: alpha2beta1 is upregulated by VEGF, alphaVbeta3 and alpha5beta1 are not, but instead are induced by bFGF, TNF and other angiogenic cytokines

Text-mined interactions from Literome

Takizawa et al., Clin Exp Immunol 1995 : These results indicate that fibronectin induced production of IL-1 alpha, IL-1 beta, TNF-alpha and IL-6 from cultured monocytes is mediated predominantly by interaction of the cell binding domain of fibronectin with VLA-5 , although Mac-1 also may contribute to this effect of fibronectin
Simms et al., Ann Surg 1997 : Ligation of CD49e upregulates TNF-alpha receptor expression, whereas binding of CD49f downregulates IL-1 beta receptor expression
Xie et al., J Biol Chem 1998 : Our results suggest that TNF-alpha may regulate macrophage differentiation and critical matrix degrading activities of myeloid progenitor cells in an autocrine manner by augmenting surface levels of the alpha5 beta1 integrin , thus promoting interactions with the extracellular matrix, a key event for maturation and migration of these cells during inflammation