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NFKB1 — TAT

Text-mined interactions from Literome

Chen et al., Am J Pathol 1999 : In the present study, we demonstrate that HIV Tat activates NF-kappaB and that this activation can be attenuated by endogenous or exogenous NO ... Inhibition of endogenous NO production with the NO synthase (NOS) inhibitor L-NMMA causes a significant increase in Tat induced NF-kappaB activity
Demarchi et al., J Virol 1999 : Tat mediated NF-kappaB activation and transcriptional induction of the HIV-1 long terminal repeat were impaired in murine cells in which the PKR gene was knocked out ... Activation of NF-kappaB by Tat required integrity of the basic domain of Tat ; previous studies have indicated that this domain is necessary for specific Tat-PKR interaction
Blázquez et al., AIDS Res Hum Retroviruses 1999 : Tat induces NF-kappaB binding to DNA as a result of IkappaBalpha phosphorylation and degradation, which depend on the intracellular redox state
Kelly et al., Virology 1999 : High levels of CAT activity were seen with HIV-LTR derived reporters that contained kappaB and TAR elements in response to transfected Tat in the absence of either transfected Rel A or exogenous TNF-alpha, and overexpression of IkappaBalpha with Tat inhibited CAT activity by 60 % to 80 %, suggesting that some activation of NF-kappaB by Tat was occurring
Kumar et al., FEBS Lett 1999 : PTPase inhibitors also blocked HIV-tat induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction
Lim et al., J Virol 2000 (Astrocytoma) : We postulate that a Tat mediated increase in SP1 binding activities augments the binding of AP1 and NF-kappaB , leading to synergistic activation of the MCP-1 promoter
Li-Weber et al., Eur J Immunol 2000 : We also show that ectopic expression of Tat protein in Jurkat T cells greatly increases NF-kappaB binding to its target DNA
Manna et al., J Immunol 2000 : Moreover, the reconstitution of JCaM1 cells with p56lck tyrosine kinase reversed the HIV-tat induced NF-kappa B activation and cytotoxicity
Ehret et al., Eur J Immunol 2001 : HIV Tat enhances activation of NF-kappaB and consequently, activates the AP-1 ( IL-2/d ) site
Li et al., Biochem Biophys Res Commun 2001 : To reconcile these differences we examined the effect of endogenous Tat on NF-kappaB activation, on IkappaB degradation and its interaction with upstream MAP3Ks ... Further analysis demonstrates that although Tat alone lacks direct effect on IkappaBalpha degradation or dissociation from NF-kappaB, Tat can substantially enhance the capacity of NF-kappaB inducing kinase (NIK) , but not MEKK1, to accelerate degradation of IkappaB
Bruce-Keller et al., J Neurochem 2001 : Inhibitor studies revealed that Tat induced NF kappa B activation was responsible for increased nitrite release, while MAPK activation mediated superoxide release, TNF alpha release, and phagocytosis
Nicolini et al., J Neurochem 2001 : Our observations indicate that NF-kappaB plays a key role in Tat dependent microglial activation, and that oxidative stress and NF-kappaB activation induced by Tat occur by independent mechanisms
Bennasser et al., J Soc Biol 2001 : Stimulation by Tat induces nuclear translocation of the transcription factor NFkB the activation of which seems to be necessary for IL-10 production
Sheng et al., Biochem Pharmacol 2003 : While U50,488 alone had a partial inhibitory effect on constituent NF-kappaB activation, it potently suppressed Tat induced NF-kappaB activation
Choi et al., Blood 2003 : The TAT-NBD blocked LPS induced NF-kappaB activation and NF-kappaB dependent gene expression
Rizzi et al., Eur J Immunol 2004 (HIV Infections) : Here we demonstrate that PTX-B inhibits Tat dependent NF-kappaB activation and HIV-1 LTR-transactivation in non-permissive epithelial HL3T1 cells in a phosphatidylinositol 3'-kinase dependent way
Guo et al., J Virol 2004 (Cell Transformation, Neoplastic...) : The HHV-8 chemokine receptor, vGPCR ( ORF74 ), activates NF-kappaB and NF-AT, and their levels of activation are synergistically increased by HIV-1 Tat
Liu et al., Am J Physiol Lung Cell Mol Physiol 2005 : Furthermore, HIV-1 Tat protein enhanced DNA binding activity of NF-kappaB , facilitated nuclear translocation of NF-kappaB subunit p65, and increased production of reactive oxygen species ( ROS ) ... Similarly to VCAM-1 expression, HIV-1 Tat protein induced NF-kappaB activation and ROS generation were abrogated by PDTC and SB-203580
Urbinati et al., J Cell Sci 2005 : alpha ( v ) beta3/Tat interaction triggers the activation of NF-kappaB in endothelial cells in a focal adhesion kinase-, RhoA- and pp60src dependent manner, as shown in dominant negative focal adhesion kinase transfectants or using specific pharmacological inhibitors ... Finally, the activation of focal adhesion kinase, RhoA, NF-kappaB and pp60src are required to mediate the motogenic activity of Tat in endothelial cells
Song et al., Exp Mol Med 2007 : In this study, we examined the effect of HIV-1 Tat on the expression of adhesion molecules, generation of reactive oxygen species ( ROS ) and NF-kappaB activation in CRT-MG human astroglioma cells ... In addition, Tat induced the activation of NF-kappaB in astrocytes ... Inhibition of Tat induced ROS generation by N-acetyl cysteine, vitamin C and diphenyl iodonium suppressed Tat induced NF-kappaB activation, ICAM-1 and VCAM-1 expression, and monocyte adhesion in CRT-MG
Jana et al., J Immunol 2007 : Involvement of NF-kappaB activation in LPS-, Abeta-, PrP-, poly IC-, Tat- , and MPP+-, but not IFN-gamma-, induced microglial expression of iNOS and stimulation of IkappaBalpha expression and inhibition of NF-kappaB activation by gemfibrozil via the PI3K pathway suggests that gemfibrozil inhibits the activation of NF-kappaB and the expression of proinflammatory molecules in microglia via PI3K mediated up-regulation of IkappaBalpha
Blanco et al., J Immunol 2008 : Interestingly, Tat did not induce NF-kappaB activity, suggesting that NF-kappaB was not necessary to control COX-2 transcription induced by Tat
Song et al., Exp Mol Med 2007 (HIV Infections) : Treatment of astrocytes with cell-permeable SOD led to decrease in Tat induced ROS generation as well as NF-kappaB activation ... These data indicate that SOD has a regulatory function for HIV-1 Tat induced NF-kappaB activation in astrocytes and suggest that cell-permeable SOD can be used as a feasible therapeutic agent for regulation of ROS related neurological diseases
Bai et al., BMC infectious diseases 2008 : The effects of HIV-1 Tat on barrier function of the RPE may be mediated by ERK MAPK and NF-kappaB activation, which may represent potential targets for novel therapeutic approaches for the retinopathy induced by HIV infection
El-Hage et al., PloS one 2008 : Taken together, these results demonstrate that : 1 ) exposure to Tat+/-morphine is sufficient to activate NF-kappaB and cytokine production, 2 ) the release of MCP-1 and IL-6 by Tat+/-morphine are highly Ca ( 2+ ) -dependent, while TNF-alpha appears to be less affected by the changes in [ Ca ( 2+ ) ] ( i ), and 3 ) in the presence of Tat , exposure to opiates augments Tat induced NF-kappaB activation and cytokine release through a Ca ( 2+ ) -dependent pathway
Lee et al., Exp Mol Med 2009 : Tat-SOD inhibited LPS induced NF-kappaB DNA binding activity, IkappaBalpha degradation and activation of MAP kinases
Jang et al., J Biol Chem 2010 (Anorexia) : In vitro, NF-kappaB activation directly stimulated the transcriptional activity of pro-opiomelanocortin (POMC), a precursor of anorexigenic melanocortin, and mediated the stimulatory effects of LPS, Tat , and pro-inflammatory cytokines on POMC transcription, implying the involvement of NF-kappaB in controlling feeding behavior
López-Huertas et al., Nucleic Acids Res 2010 : First, NF-kappaB- , NF-AT- and Sp1 dependent transcriptional activities were greatly enhanced in Jurkat-Tat101, whereas Tat72 induced milder but efficient activation
Harhaj et al., Virology 1996 : In the present study, we demonstrate that Tat transactivation of the HIV-1 LTR is markedly inhibited by several cytoplasmic inhibitors of NF-kappa B/Rel , suggesting the critical involvement of these host transcription factors in the function of the viral Tat protein
Demarchi et al., J Virol 1996 : The effects of Tat on the enhancer are mediated by Tat induced nuclear translocation of NF-kappaB , which parallels the kinetics of transcriptional activation ... These results show that NF-kappaB activation by Tat is important for LTR transcriptional activation
Kelly et al., AIDS 1998 (AIDS-Related Opportunistic Infections...) : Tat and TNFalpha activated comparable levels of NF-kappaB