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COPS5 — JUN

Pathways - manually collected, often from reviews:

• BioCarta hypoxia-inducible factor in the cardivascular system: HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) → Endothelin 1 (EDN1) (transcription, activates)
• BioCarta hypoxia-inducible factor in the cardivascular system: ARNT → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, collaborate)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: p300 (EP300) → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, collaborate)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: CREB (CREB1) → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, collaborate)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: JAB1 (COPS5) → c-JUN (JUN) (modification, collaborate)
• BioCarta hypoxia-inducible factor in the cardivascular system: JAB1 (COPS5) → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, collaborate)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: HIF-1-alpha (HIF1A) → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, collaborate)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: aspartylpeptide beta-dioxygenase (ASPH) → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, inhibits)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: c-JUN (JUN) → HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) (modification, collaborate)
  
• BioCarta hypoxia-inducible factor in the cardivascular system: HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) → VEGF (transcription, activates)
• BioCarta hypoxia-inducible factor in the cardivascular system: HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN) → l-lactate dehydrogenase (LDHA) (transcription, activates)
  
• NCI Pathway Database AP-1 transcription factor network: JUN/JUN-FOS complex (JUN-FOS_JUN) → JAB1 (COPS5) (modification, collaborate) Claret et al., Nature 1996*
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/JUN-FOS complex (JUN-FOS_JUN) → JUN/JUN-FOS/JAB1 complex (JUN-FOS_JUN-COPS5) (modification, collaborate)
  Claret et al., Nature 1996*
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JAB1 (COPS5) → JUN/JUN-FOS/JAB1 complex (JUN-FOS_JUN-COPS5) (modification, collaborate)
  Claret et al., Nature 1996*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: COPS5 — JUN (direct interaction, enzymatic study) Kapelari et al., J Mol Biol 2000
• IRef Biogrid Interaction: COPS5 — JUN (direct interaction, pull down) Bianchi et al., Nature 2000*
• IRef Biogrid Interaction: COPS5 — JUN (physical association, affinity chromatography technology) Yun et al., J Biol Chem 2010*
• IRef Biogrid Interaction: COPS5 — JUN (direct interaction, two hybrid) Claret et al., Nature 1996*
• IRef Biogrid Interaction: COPS5 — JUN (physical association, affinity chromatography technology) Claret et al., Nature 1996*
• IRef Biogrid Interaction: COPS5 — JUN (colocalization, imaging technique) Claret et al., Nature 1996*
• IRef Hprd Interaction: COPS5 — JUN (in vitro) Claret et al., Nature 1996*
• IRef Ophid Interaction: COPS5 — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: COPS5 — JUN (aggregation, confirmational text mining) Claret et al., Nature 1996*

Text-mined interactions from Literome

Kapelari et al., J Mol Biol 2000 : The modification of COP9 signalosome subunit 2 might be essential for c-Jun phosphorylation
Lee et al., Cell Growth Differ 1997 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, the inhibitory effect of t-RA on AP-1 transcriptional activity was not restored in tumorigenic 11701 cells by transfection of c-fos, silencing mediator for retinoid and thyroid hormone receptors, Jun activation domain binding protein 1 , or CREB binding protein, suggesting the involvement of other transcriptional coregulators in this retinoid signaling defect