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BRCA1 — E2F6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wang et al., J Biol Chem 2000
(Breast Neoplasms...) :
Moreover, ectopic expression of cyclin D1 and Cdk4 can stimulate the
Brca1 promoter in an
E2F dependent manner, and this is inhibited by coexpression of the p16(INK4a) cyclin dependent kinase inhibitor
Oberley et al., J Biol Chem 2003
:
E2F6 negatively
regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9
Yang et al., Cell Death Differ 2007
:
Furthermore, these
effects of
E2F6 on
BRCA1 depended upon the association of E2F6 with BRCA1 via its C-terminus in a UV-triggered manner and upon the transcriptional repression by E2F6 on the BRCA1 promoter
Bindra et al., Cancer Biol Ther 2006
(Breast Neoplasms...) :
We have shown recently that the tumor microenvironmental stress of hypoxia induces an
E2F dependent repression of
BRCA1 in cancer cells