O'toole et al., Biochem J 2001
:
We conclude that, at physiological concentrations, TNF-alpha activates endogenous PKB by stimulating PDK2 ( increase in Ser ( 473 ) phosphorylation ) in a PI3-kinase dependent ( wortmannin-sensitive ) manner, without causing detectable stimulation of PDK1 ( no increase in Thr ( 308 ) phosphorylation ) or ARNO translocation
Shibata et al., Biochem Pharmacol 2008
(Neovascularization, Pathologic) :
Western blot analysis revealed that the anti-angiogenic effect of delta-T3 is attributable to regulation of growth factor dependent phosphatidylinositol-3 kinase (PI3K)/phosphoinositide dependent protein kinase ( PDK ) /Akt signaling as well as to induction stress response in endothelial cells