Shih et al., Cancer Lett 2010
:
AMF/PGI induced PI 3-kinase activity, IRS and Akt phosphorylation, which can further regulate BAD phosphorylation
Kho et al., Cancer Res 2013
(Breast Neoplasms) :
Mechanistic investigations indicated that interaction of AMF with HER2 triggers HER2 phosphorylation and metalloprotease mediated ectodomain shedding, activating phosphoinositide-3-kinase (PI3K) and mitogen activated protein kinase signaling and ablating the ability of trastuzumab to inhibit breast carcinoma cell growth