Gene interactions and pathways from curated databases and text-mining

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EPHB2 — MUC8

Text-mined interactions from Literome

Kim et al., J Korean Med Sci 2002 (MAP Kinase Signaling System) : PD98059 ( MEK/ERK inhibitor ) suppressed IL-1beta mediated MUC2 gene expression and mucin secretion, while SB203580 ( p38 inhibitor ) did not
Alcaide et al., Eur J Immunol 2004 (Chagas Disease) : Furthermore, AgC10 inhibition must lie upstream in the MAPK activation pathway by LPS, since this mucin also inhibited extracellularly regulated kinase (ERK) and Jun kinase (JNK)activation
Cho et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Here, we show that ERK mitogen activated protein kinase is essential for PGE2 induced MUC8 gene expression in normal human nasal epithelial cells and that p90 ribosomal S 6 protein kinase 1 (RSK1) mediates the PGE2 induced phosphorylation of cAMP-response element binding protein
Lim et al., American journal of translational research 2009 : In the present study, we showed that positive regulation of MUC5AC mucin expression by ERK1/2 is dependent on Ras-Raf-1 signaling pathway, whereas the negative regulation of MUC5AC expression by JNK1/2 is dependent on MEKK3 ... Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates MUC5AC mucin induction by S. pneumoniae, whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it