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EDN1 — EPHB2

Text-mined interactions from Literome

Vichi et al., J Biol Chem 1999 : For example, nine point mutations within TM7 of the ETB were identified that prevented endothelin stimulated ERK activation
Leopoldt et al., J Cell Physiol 2000 : Stimulation of these cells with bombesin, lysophosphatidic acid (LPA), endothelin , and platelet derived growth factor ( PDGF ) led to a marked increase in the tyrosine phosphorylation of these focal adhesion proteins and in ERK activation
Clerk et al., Mol Cell Biol 2001 (Cardiomegaly) : In transfection experiments, dominant negative N17Rac1 inhibited activation of ERK by endothelin 1 , whereas activated V12Rac1 cooperated with c-Raf to activate ERK
Cramer et al., Eur J Biochem 2001 (MAP Kinase Signaling System) : Endothelin-1 stimulation of wild-type ET ( A ) or ET ( B ) induced a fivefold to sixfold increase in ERK in COS-7 and CHO cells whereas full-length nonpalmitoylated ET ( A ) and ET ( B ) mutants failed to stimulate ERK ... Using mutated ET receptors with selective G-protein coupling we found that endothelin induced stimulation of G ( alpha ) q, but not of G ( alpha ) i or G ( alpha ) s, is essential for endothelin mediated ERK activation
Kawanabe et al., Eur J Pharmacol 2002 (Brain Neoplasms...) : An inhibitor of mitogen activated protein kinase, 2- [ 2-amino-3-methoxyphenyl ] -4H-1-benzopyran-4-one ( PD 98059 ), abolished the endothelin-1 induced increase in ERK1/2 activity, but only partially suppressed the mitogenic response ... ERK1/2 activation by endothelin-1 was partially suppressed in the absence of extracellular Ca2+ ... These results indicate that ( 1 ) the endothelin-1 induced mitogenic response involves both ERK1/2 dependent and -independent mechanisms, ( 2 ) ERK1/2 activation by endothelin-1 involves an extracellular Ca2+ influx dependent cascade as well as an extracellular Ca2+ influx independent cascade, ( 3 ) because endothelin-1 induced mitogenesis is completely dependent on extracellular Ca2+ influx, extracellular Ca2+ influx also plays an important role in mitogenic pathways downstream of ERK1/2, ( 4 ) extracellular Ca2+ influx through NSCC-1 and NSCC-2 has an important role in the extracellular Ca2+ influx dependent component of ERK1/2 dependent mitogenesis, ( 5 ) extracellular Ca2+ influx through NSCC-2 has an important role in ERK1/2 independent mitogenesis, and ( 6 ) Ca2+ influx through each Ca2+ channel may play a distinct role in intracellular mitogenic cascades
Kodama et al., J Mol Cell Cardiol 2002 (MAP Kinase Signaling System) : Role of EGF Receptor and Pyk2 in endothelin-1 induced ERK activation in rat cardiomyocytes
Zeidan et al., Arterioscler Thromb Vasc Biol 2003 : Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch : role of endothelin-1
Li et al., Circ Res 2004 (MAP Kinase Signaling System) : PGI2 or iloprost at the IP receptor inhibited basal ERK phosphorylation with IC50 values of 10 nmol/L. Iloprost also attenuated the sustained activation of ERK induced by endothelin-1 or basic fibroblast growth factor (bFGF)
Daou et al., Free Radic Biol Med 2004 : Reactive oxygen species mediate Endothelin-1 induced activation of ERK1/2 , PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells
Asada et al., J Cardiovasc Pharmacol 2004 : Cytodifferentiation enhances Erk activation induced by endothelin-1 in primary cultured astrocytes
Hassan et al., Infect Immun 2006 (Chagas Disease) : ERK activates endothelin-1 , which in turn exerts positive feedback activating ERK, and cyclin D1 is a downstream target of both endothelin-1 and ERK
Bouallegue et al., Am J Physiol Heart Circ Physiol 2007 (Hypertrophy) : Nitric oxide attenuates endothelin-1 induced activation of ERK1/2 , PKB, and Pyk2 in vascular smooth muscle cells by a cGMP dependent pathway
Morishita et al., Neurosci Res 2007 : Endothelin induced ERK phosphorylation was independent of integrin ligands, and an inhibitor of G ( q/11 ), YM-254890, as well as pertussis toxin, partially inhibited endothelin stimulated phosphorylation of Raf-1 and ERK ... A PKC inhibitor and down-regulation of PKC prevented endothelin induced phosphorylation of paxillin and ERK
Dorado et al., Nephrol Dial Transplant 2008 : In cultured human mesangial cells, Erk5 was activated by foetal calf serum ( FCS ), high glucose, endothelin-1 , platelet activating factor (PAF), epidermal growth factor (EGF) and transforming growth factor beta-1 ( TGF-beta1 ) ... In cultured human mesangial cells, Erk5 was activated by foetal calf serum ( FCS ), high glucose, endothelin-1 , platelet activating factor (PAF), epidermal growth factor (EGF) and transforming growth factor beta-1 ( TGF-beta1 )
Tencheva et al., Neurosci Behav Physiol 2008 (Brain Neoplasms...) : The invasive growth, proliferation, and transcriptional regulation of glioma C6 cells treated with endothelin-1 and PD98059, a specific inhibitor of ERK1/2 were studied
Kobayashi et al., Br J Pharmacol 2008 (Diabetes Mellitus, Experimental...) : ET ( A ) and ET ( B ) receptors, ERK-1/2 and MEK-1/2 protein expression and endothelin-1 stimulated ERK phosphorylation were all increased in aortae from insulin treated diabetic rats
Zhan et al., Gastroenterology 2009 (Disease Models, Animal) : In these cells, fibronectin induced phosphorylation/activation of extracellular signal regulated kinase ( ERK ) through a Shc- and Src dependent mechanism ; ERK activation was required for fibronectin induced endothelin-1 expression
Chen et al., BMC cell biology 2009 : Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells
Wu et al., Can J Physiol Pharmacol 2010 (Diabetes Mellitus, Experimental) : Glucose induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats
Nakajima et al., Arch Dermatol Res 2011 (Melanoma) : Signaling analysis with specific inhibitors and immunoblots revealed that in melanoma cells treated with the extract, there was a marked deficiency in the EDN1 stimulated phosphorylation of Raf-1, MEK, ERK , MITF and CREB
Sallum et al., Chem Biol Drug Des 2012 (MAP Kinase Signaling System) : We investigated the effect of a TAT linked intracellular third loop of the endothelin-1 type B receptor on endothelin-1 activation of ERK ... In the normal human pulmonary artery smooth muscle cells, the peptide marginally enhanced endothelin-1 activation of ERK ... However, it markedly enhanced the endothelin-1 activation of ERK in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells ... While the effective concentration for endothelin-1 activation of ERK remained unchanged in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells, the number of ETB receptors declined by 2/3
Kapakos et al., Can J Physiol Pharmacol 2012 (MAP Kinase Signaling System) : Attenuation of endothelin-1 induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells
Aquilla et al., J Biol Chem 1996 : The observed ERK activation appeared to be mediated by heterotrimeric G proteins, since ectopic expression of a transducin alpha-subunit inhibited endothelin stimulated ERK activation
Zou et al., J Biol Chem 1996 : Overexpression of a dominant negative mutant of Raf-1 completely suppressed ERK2 activation by AngII, endothelin-1 , and insulin
Cadwallader et al., Biochem J 1997 : The activation of ERK1 by lysophosphatidic acid (LPA) and endothelin 1 (Et-1) was compared in Rat-1 cells
Alexandrov et al., Mol Pharmacol 1998 : In Rat-1 fibroblasts, endothelin-1 and a protein kinase C-stimulating phorbol ester stimulated extracellular signal regulated kinase ( ERK ), whereas phenylephrine, acting at stably transfected human alpha1A-adrenoceptors, inhibited basal and endothelin-1- and phorbol ester stimulated ERK