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IFNG — MS4A1
Text-mined interactions from Literome
Treon et al., Semin Oncol 1999
(Multiple Myeloma...) :
As a potential strategy to overcome this limitation, we demonstrated that
interferon-gamma at pharmacologically achievable levels
induced CD20 expression on these CD20- plasma cells, consistent with our recent findings that interferon-gamma is a potent inducer of CD20 expression on MM patient plasma cells and B cells ... Our studies further suggest that
interferon-gamma may
enhance CD20 expression on MM plasma cells, thereby increasing their susceptibility to anti-CD20 monoclonal antibody therapies
Treon et al., Semin Oncol 2000
(Multiple Myeloma...) :
The use of agents to induce MM- and WM-selective antigens for targeting in serotherapy has been proposed based on studies demonstrating the
upregulation of
CD20 by
interferon-gamma (IFN-gamma) , and of MUC1 core protein by dexamethasone ( DEX ) on malignant plasma cells
Treon et al., J Immunother 2002
(Multiple Myeloma) :
Furthermore,
IFN-gamma induces
CD20 expression on MM BMPCs and B cells and facilitates rituximab binding to MM BMPCs, providing the rationale for clinical trials to examine its use with CD20 directed serotherapies in MM