◀ Back to EPHB2

EPHB2 — SMAD4

Text-mined interactions from Literome

Iglesias et al., Oncogene 2000 (Carcinoma...) : These results suggest that Smad4 acts inhibiting Ras dependent Erk signalling activity in Ras transformed keratinocytes
Leask et al., J Biol Chem 2003 : Now we show that protein kinase C and Ras/MEK/ERK are necessary for the TGF-beta induction of the CTGF promoter but not of a generic Smad-responsive promoter ( SBE-lux )
Hayashida et al., FASEB J 2003 (MAP Kinase Signaling System) : These results indicate that ERK dependent R-Smad linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells
Kfir et al., Mol Cell Biol 2005 : Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and Erk mediated interference with Smad signaling
Wang et al., Circ Res 2006 (Arteriosclerosis...) : This was extracellular signal regulated kinase 1/2 ( ERK1/2 ) mitogen activated protein kinase ( MAPK ) dependent but transforming growth factor-beta ( TGF-beta ) independent because Ang II-induced Smad signaling was blocked by addition of ERK1/2 inhibitor and by dominant negative ( DN ) ERK1/2 but not by DN-TGF-beta receptor II (TbetaRII) or conditional deletion of TbetaRII
Zhou et al., J Allergy Clin Immunol 2007 (Asthma...) : These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive effect of IL-13 induced ERK on Smad signaling
Sebestyén et al., Exp Cell Res 2007 (Lymphoma, B-Cell) : Moreover, functional inhibition of Smad4 had no influence on TGFb induced apoptosis, but it was dependent on PP2A phosphatase activation, ERK1/2 and JNK inactivation in lymphoma cells
Heger et al., J Cell Physiol 2010 (Cardiomegaly...) : Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ERK ( 10 microM PD98059 ) also blocked GDF15 induced hypertrophy and SMAD activation
Yu et al., Mol Endocrinol 2013 : Our results also indicated that SMAD4 was required for LH-stimulated activation of ERK1/2 and the expressions of ovulation related genes