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NOS1 — PARP3
Text-mined interactions from Literome
Hwang et al., J Neurochem 2002
:
These results suggest that NADPH oxidase and
nNOS contribute to increased oxidative stress, subsequent activation of
PARP/PARG , and neuronal death induced by prolonged neurotrophin exposure
Wang et al., Ann N Y Acad Sci 2003
(Disease Models, Animal...) :
The mechanisms of MPTP induced neurotoxicity are not yet fully understood but involve activation of N-methyl-D-aspartate ( NMDA ) receptors by glutamate, production of NO by
nNOS and iNOS, oxidative injury to DNA, and
activation of the DNA damage sensing enzyme poly ( ADP-ribose ) polymerase (
PARP )
von Lukowicz et al., Cardiovasc Res 2008
(Atherosclerosis...) :
PARP inhibition or PARP1 deletion
reduced PARP activity and diminished expression of inducible
nitric oxide synthase , vascular cell adhesion molecule-1, and P- and E-selectin
Braidy et al., Neurotox Res 2009
:
We have shown that the NMDA ion channel blockers, MK801 and memantine, and the
nitric oxide synthase (NOS) inhibitor, L-NAME, significantly
attenuate QUIN mediated
PARP activation, NAD ( + ) depletion, and LDH release in both neurons and astrocytes