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PLD1 — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PLD1 → RAC1 (increases, RAC1 Activity, PLD1 Activity)
  Evidence: Studies in human T cells show that both RAC1 and RHOA are required to transduce chemokine receptor signals to the activation of LFA1 by phospholipase D and PIP5K1gamma106 (Fig. 5).

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PLD1 — RAC1 (in vivo) Powner et al., Mol Biol Cell 2002*
• IRef Ophid Interaction: PLD1 — RAC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: PLD1 — RAC1 (interaction, mapped from kegg_pathways)
• STRING interaction: RAC1 — PLD1 (interaction, mapped from grid kegg_pathways mint intact)

Text-mined interactions from Literome

Santy et al., J Cell Biol 2001 : However, inhibition of PLD does not prevent activation of Rac
Powner et al., FEBS Lett 2002 : In agonist stimulated cells, however, there is specificity, with, for example in RBL-2H3 cells, antigen stimulating the activation of PLD1 by association with Arf6, Rac1 and protein kinase Calpha
Momboisse et al., J Cell Sci 2009 : Finally, we show that the presence of the scaffolding protein Scrib at the plasma membrane is essential for betaPix/Rac1 mediated PLD1 activation and exocytosis
Hess et al., J Biol Chem 1997 : In contrast, in cells treated with platelet derived growth factor ( PDGF ) or phorbol ester, the wtRac1 cells showed little or no enhancement of PLD activity, and the response was not affected in the N17Rac1 cells, implying that Rac1 played a minimal role in the activation of PLD by PDGF or protein kinase C ... In summary, these data indicate a major role for Rac1 in the activation of PLD by EGF, but not PDGF or protein kinase C