◀ Back to CCNB1

CCNB1 — TAT

Text-mined interactions from Literome

Sun et al., Int J Radiat Oncol Biol Phys 2006 (Acquired Immunodeficiency Syndrome) : Moreover, HIV-1 Tat resulted in a constitutive overexpression of cyclin B1 protein
Zhang et al., FASEB J 2010 (HIV Infections) : HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation ... Here, we show that HIV encoded Tat protein regulates cyclin B1 levels in two different ways : first, Tat stimulates the transcription of cyclin B1 , which increases cyclin B1 levels and promotes the cells apoptosis ; and second, Tat stimulates polyubiquitination mediated degradation of cyclin B1 through binding to the N-terminal of cyclin B1 ( aa 61-129 ) that is just downstream of the D box, which prevents excessive levels of cyclin B1 in the cells ... These results suggest that Tat regulating cyclin B1 affects the status of HIV : Tat stimulates cyclin B1 expression to slow down the host cell cycle progress and to promote the host cell apoptosis, which might facilitate HIV release ; Tat stimulates cyclin B1 degradation to prevent overaccumulation of cyclin B1, which might facilitate HIV replication ... Taken together, our results reveal for the first time how HIV-Tat regulates cyclin B1 and keeps its balance in the cells