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CCNE1 — FOXM1

Pathways - manually collected, often from reviews:

• NCI Pathway Database FOXM1 transcription factor network: RB1/FOXM1C complex (FOXM1-RB1) → Cyclin A-E1/CDK1-2 complex (CCNA2_CCNE1-CDK2) (modification, collaborate)
  Lüscher-Firzlaff et al., FEBS Lett 2006, Wierstra et al., Biochem Biophys Res Commun 2006, Wierstra et al., Biol Chem 2006
  Evidence: mutant phenotype, assay, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCNE1 — FOXM1 (physical association, affinity chromatography technology) Major et al., Mol Cell Biol 2004
• IRef Biogrid Interaction: CCNE1 — FOXM1 (direct interaction, enzymatic study) Lüscher-Firzlaff et al., FEBS Lett 2006
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Lüscher-Firzlaff et al., FEBS Lett 2006
• IRef Intact Interaction: CCNE1 — FOXM1 (physical association, pull down) Lüscher-Firzlaff et al., FEBS Lett 2006
• IRef Intact Interaction: CCNE1 — FOXM1 (phosphorylation reaction, protein kinase assay) Lüscher-Firzlaff et al., FEBS Lett 2006

Text-mined interactions from Literome

Lüscher-Firzlaff et al., FEBS Lett 2006 : Regulation of the transcription factor FOXM1c by Cyclin E/CDK2
Wierstra et al., Biochem Biophys Res Commun 2006 : Cyclin E/Cdk2 activates FOXM1c by releasing its transactivation domain from the repression by these two inhibitory domains