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SPP1 — TLR4
Text-mined interactions from Literome
Samuvel et al., J Biol Chem 2010
:
Moreover, lipopolysaccharide or palmitic acid induced
TLR4 activation and high glucose further
augmented the coculture stimulated
osteopontin secretion
Salvi et al., J Leukoc Biol 2013
:
Dual
regulation of
osteopontin production by
TLR stimulation in dendritic cells ... Here, we report that the activation of the MyD88 pathway by TLR2,
TLR5 , and TLR7/8 agonists or IL-1ß
induces high levels of
OPN in human DCs ... These results highlight the biological relevance of the differential
OPN induction by TLR2 and
TLR4 agonists and emphasize the importance of TLR cross-talk in OPN induction ... This implies that
OPN regulation by
TLR signaling is critical in shaping inflammatory responses and may modulate IL-17 production in response to pathogens