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CA2 — CREB5
Text-mined interactions from Literome
Ledo et al., EMBO J 2002
:
Ca2+ dependent block of
CREB-CBP transcription by repressor DREAM ... Thus,
Ca2+ dependent interactions between DREAM and
CREB represent a novel point of cross-talk between cAMP and Ca2+ signalling pathways in the nucleus
Barlow et al., Am J Respir Cell Mol Biol 2006
:
In this study, we tested the hypotheses that oxidants induce
Ca2+ mediated phosphorylation of ERK and
CREB , and that CREB is required for oxidant induced proliferation and apoptosis
Mathieson et al., Br J Pharmacol 2006
:
Sphingolipids differentially
regulate mitogen activated protein kinases and intracellular
Ca2+ in vascular smooth muscle : effects on
CREB activation
Huang et al., J Neurosci 2006
:
These Ng-/- mice, as compared with Ng+/+, respond poorly after treatment of their hippocampal slices with agents that activate signaling molecules important for learning and memory, including
Ca2+/calmodulin dependent protein kinase II ( alphaCaMKII ), PKC, protein kinase A (PKA), extracellular signal regulated kinase ( ERK ), and cAMP response element binding protein (
CREB )
Rosethorne et al., Biochem Pharmacol 2008
(Neuroblastoma...) :
Removal of extracellular
Ca2+ , inhibition of Ca2+/calmodulin dependent protein kinase II and down-regulation of protein kinase C ( PKC )
resulted in reduced
CREB phosphorylation after both M3 mACh and B2 bradykinin receptor activation
Schwaninger et al., J Biol Chem 1995
:
Gene transcription can be
induced by cAMP and
Ca2+ through distinct protein kinases phosphorylating the transcription factor
CREB , which binds to cAMP response elements ( CREs ) in various genes
Matthews et al., Mol Cell Biol 1994
:
In neurons and other cell types,
CREB phosphorylation and activation of CRE containing promoters can occur in
response to elevated intracellular
Ca2+
Takuma et al., Biochem Mol Biol Int 1997
:
Regulation of
CREB phosphorylation by cAMP and
Ca2+ in parotid acinar cells
Ahn et al., Mol Cell Biol 1998
:
A-CREB completely inhibited cAMP mediated, but only partially
inhibited Ca2+- and NGF mediated, transcription of a reporter gene containing 750 bp of the native c-fos promoter
Rajadhyaksha et al., Dev Neurosci 1998
:
Here we present the
role of N-methyl-D-aspartate receptors and
Ca2+ in cyclic AMP mediated
CREB phosphorylation
Duman et al., J ECT 1998
:
Studies in vivo and in cultured cells indicate that the induction of BDNF and TrkB is mediated by the cyclic adenosine monophosphate ( cAMP ) response element binding protein (
CREB ), a transcription factor that is
activated by cAMP and
Ca2+ intracellular pathways
Impey et al., Neuron 1998
(Calcium Signaling) :
The sequential activation of ERK and Rsk2 by
Ca2+ leads to the phosphorylation and transactivation of
CREB