Gene interactions and pathways from curated databases and text-mining

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GDF15 — JUN

Text-mined interactions from Literome

Tiberio et al., PloS one 2010 (Neoplasms) : We provided evidence that 4-oxo-4-HPR, besides acting as an antimicrotubule agent, induced apoptosis through a signaling cascade starting from ROS generation and involving endoplasmic reticulum ( ER ) stress response, Jun N-terminal Kinase (JNK) activation , and upregulation of the proapoptotic PLAcental Bone morphogenetic protein ( PLAB )
Alvarez et al., BMC bioinformatics 2011 (Carcinoma...) : The top regulatory relationships identified by RegNetB include the regulation of RLN1, RLN2, by PAX4, the regulation of ACPP ( PAP ) by JUN , BACH1 and BACH2, and the co-regulation of PGC and GDF15 by MAZ and TAF8
Tiberio et al., PloS one 2012 (Ovarian Neoplasms) : We previously showed that in ovarian cancer cells, 4-HPR induces apoptosis through a signaling cascade starting from reactive oxygen species ( ROS ) generation and involving endoplasmic reticulum ( ER ) stress response, Jun N-terminal Kinase (JNK) activation, and induction of the proapoptotic PLAcental Bone morphogenetic protein ( PLAB )