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CDKN1A — PML

Text-mined interactions from Literome

Yang et al., Mol Cell Biol Res Commun 1999 : Transcriptional activation of the cyclin dependent kinase inhibitor p21 by PML/RARalpha ... We showed in this study that PML/RARalpha increased the transcription of p21WAF1/CIP1 gene and the activation was further induced by RA treatment ... Transient transfection of PML/RARalpha in cells increased the endogenous p21WAF1/CIP1 protein levels
Son et al., Cancer Lett 2007 (Breast Neoplasms) : We concluded that PML and all-trans-retinoic acid cause cell death by different pathways : PML activates ERK1/2, p38 MAPK, and p21 ; arrests the cell cycle ; and later causes cell death ; and all-trans-retinoic acid activates proteasome function, caspase cleavage, and apoptosis
Yang et al., Cancer Cell 2010 (Neoplasms) : Furthermore, activated BMK1 notably inhibited PML dependent activation of p21
Rokudai et al., Proc Natl Acad Sci U S A 2013 (Leukemia, Promyelocytic, Acute) : As a result of PML mediated suppression of Akt, the increased PML-MOZ interaction enhances p21 expression and induces p53 dependent premature senescence upon forced PML expression