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E4F1 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: E4F1 (E4F1) → p53 (tetramer) complex (TP53) (modification, activates)
  Le Cam et al., Cell 2006, Gu et al., Cell 1997*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: E4F1 — TP53 (physical association, affinity chromatography technology) Rizos et al., J Biol Chem 2003*
• IRef Biogrid Interaction: E4F1 — TP53 (direct interaction, two hybrid) Sandy et al., Oncogene 2000*
• IRef Biogrid Interaction: E4F1 — TP53 (direct interaction, pull down) Sandy et al., Oncogene 2000*
• IRef Biogrid Interaction: E4F1 — TP53 (physical association, affinity chromatography technology) Sandy et al., Oncogene 2000*
• IRef Hprd Interaction: TP53 — E4F1 (in vitro) Sandy et al., Oncogene 2000*, Rizos et al., J Biol Chem 2003*, Le Cam et al., Cell 2006
• IRef Hprd Interaction: TP53 — E4F1 (in vivo) Sandy et al., Oncogene 2000*, Rizos et al., J Biol Chem 2003*, Le Cam et al., Cell 2006
• IRef Ophid Interaction: E4F1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sandy et al., Oncogene 2000 : Ectopic expression of p120E4F leads to a block of cell proliferation in several human and murine cell lines and this effect requires the association with wild-type ( wt ) p53
Chagraoui et al., Genes Dev 2006 : Using cell lines and MEF, we also demonstrate that INK4A/ARF and p53 are not essential for functional interaction between Bmi1 and E4f1