Gene interactions and pathways from curated databases and text-mining

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BRAF — NGF

Pathways - manually collected, often from reviews:

  • Reactome Reaction: BRAF → NGF (reaction)
  • Reactome Reaction: BRAF → NGF (indirect_complex)

Text-mined interactions from Literome

MacNicol et al., J Biol Chem 1999 : We report that nerve growth factor stimulated B-Raf activity is not inhibited by PKA
MacNicol et al., J Biol Chem 2000 : Expression of the isolated B-Raf catalytic domain (B-Rafcat) induces PC12 cell differentiation in the absence of nerve growth factor
Troppmair et al., Oncogene 1992 : We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf PSK stimulation by nerve growth factor (NGF) in PC12 pheochromocytoma cells
Stephens et al., Mol Cell Biol 1992 : Induction of B-Raf kinase activity in NGF treated PC12 cells required expression of kinase-active trk receptors
Peraldi et al., FEBS Lett 1995 : We observed that NGF , PMA and cAMP induce the phosphorylation of B-Raf as well as an upward shift in its electrophoretic mobility
Vaillancourt et al., Mol Cell Biol 1994 : In response to epidermal growth factor, nerve growth factor , and platelet derived growth factor, B-Raf and Raf-1 are activated, phosphorylate recombinant kinase-inactive MEK-1, and activate wild-type MEK-1
Jaiswal et al., Mol Cell Biol 1994 : The mitogen activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras ... These data provide direct evidence that NGF stimulated B-Raf is responsible for the activation of the MAP kinase cascade in PC12 cells, whereas c-Raf1 activity was not found to function within this pathway
Lange-Carter et al., Science 1994 : Stimulation of synthesis of cyclic adenosine 3',5'-monophosphate abolished activation of MEKK and B-Raf by EGF, NGF , and TPA