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AKT2 — WAS

Text-mined interactions from Literome

Ozaita et al., J Neurochem 2007 : Moreover, PI3K inhibition by wortmannin abrogated THC induced phosphorylation of Akt , but blockade of extracellular signal regulated protein kinases by SL327 did not modify this activation/phosphorylation of Akt
Salazar et al., Biochim Biophys Acta 2013 (Neoplasms, Experimental) : We also show that genetic inactivation of this protein abolishes the ability of THC to inhibit the phosphorylation of AKT and several of its downstream targets, including those involved in the regulation of the AKT/mammalian target of rapamycin complex 1 ( mTORC1 ) axis ... Our data support the idea that THC induced TRIB3 up-regulation inhibits AKT phosphorylation by regulating the accessibility of AKT to its upstream activatory kinase ( the mammalian target of rapamycin complex 2 ; mTORC2 )