◀ Back to SMAD3
CDK2 — SMAD3
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
SMAD3
→
CDK2
(directlyIncreases, SMAD3 Activity)
Evidence: 15241418;15520018;10197981
-
OpenBEL Selventa BEL large corpus:
SMAD3
→
CDK2
(directlyIncreases, SMAD3 Activity)
Evidence: 15241418;15520018;10197981;16156666
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
SMAD3
—
CDK2
Matsuura et al., Nature 2004
-
IRef Bind_translation Interaction:
SMAD3
—
CDK2
(experimental interaction detection)
Matsuura et al., Nature 2004
-
IRef Biogrid Interaction:
SMAD3
—
CDK2
(direct interaction, enzymatic study)
Matsuura et al., Nature 2004
-
IRef Hprd Interaction:
CDK2
—
SMAD3
(in vitro)
Matsuura et al., Nature 2004
-
IRef Hprd Interaction:
CDK2
—
SMAD3
(in vivo)
Matsuura et al., Nature 2004
-
IRef Ophid Interaction:
SMAD3
—
CDK2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
STRING interaction:
CDK2
—
SMAD3
(interaction, mapped from kegg_pathways)
-
STRING interaction:
SMAD3
—
CDK2
(interaction, mapped from grid bind kegg_pathways)
Text-mined interactions from Literome
Tomic et al., Biol Reprod 2002
(Body Weight) :
Further, the results indicate that
Smad 3 may
regulate the expression of Bax and Bcl-2, but not Bcl-x,
Cdk-2 , and PCNA
Zelivianski et al., Mol Cancer Res 2010
(Breast Neoplasms) :
Inhibition of
CDK mediated
Smad3 phosphorylation released cyclin D1-regulated blockade of Smad3 transcriptional activity and recovered cell cycle arrest in breast cancer cells
Cooley et al., Cell cycle (Georgetown, Tex.) 2010
(Breast Neoplasms) :
Overexpression of the cell cycle mitogen, cyclin E, is associated with poor prognosis in breast cancer, and cyclin
E/CDK2 mediated phosphorylation of
Smad3 has been linked with inhibition of Smad3 activity ... Thus, cyclin E-mediated inhibition of
Smad3 is
regulated by
CDK2 phosphorylation of the Smad3 protein in MCF7 cells
Cheng et al., Chem Biol 2012
(MAP Kinase Signaling System) :
We found that indirubin derivative E738 inhibited both TGFß and BMP pathways through ubiquitin-proteasome mediated depletion of total R-Smad pools, although
phospho-R-Smad levels were initially
stabilized by GSK3ß and
cyclin dependent kinase inhibition