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IFNB1 — IL8

Text-mined interactions from Literome

Lou et al., Lab Invest 1999 (Multiple Sclerosis) : Furthermore IFN-beta did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC, but partially reduced TNF and interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC
Yao et al., J Interferon Cytokine Res 2001 : Regulation by IFN-beta of inducible nitric oxide synthase and interleukin-12/p40 in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens
Dalod et al., J Exp Med 2002 : Interferon alpha/beta and interleukin 12 responses to viral infections : pathways regulating dendritic cell cytokine expression in vivo
Bahner et al., Neurosci Lett 2002 (Multiple Sclerosis, Chronic Progressive) : Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Tamura et al., Infect Immun 1992 : Therefore, endogenous IFN-beta enhanced IL-8 mRNA production in response to B. intermedius LPS in fibroblasts
Heim et al., Med Microbiol Immunol 2004 : We investigated whether the higher antiviral activity of IFN-beta compared to IFN-alpha was a result of a suppression of IL-8 expression by IFN-beta since previous studies had indicated that IL-8 stimulates enterovirus replication ... Both IFN-beta and IFN-gamma reduced IL-6 and IL-8 expression significantly
Oliveira et al., Proc Natl Acad Sci U S A 1992 : Earlier we showed that TNF induced stimulation of IL-8 mRNA accumulation in human FS-4 fibroblasts was inhibited by interferon beta (IFN-beta) or IFN-gamma ... Here we show that this inhibition is not specific for TNF, since IFN-beta also reduced IL-8 mRNA accumulation induced by IL-1 or the double stranded RNA poly ( I-C ) ... Nuclear run-on assays demonstrated that IFN-beta caused a marked inhibition of TNF induced IL-8 gene transcription ; the transcriptional activation of several other TNF induced genes was not inhibited by IFN-beta
van Holten et al., Arthritis Res Ther 2004 (Arthritis, Experimental...) : IFN-beta reduced expression of IL-6, IL-8 , and GM-CSF in RA and osteoarthritis fibroblast-like synoviocytes, correlating with reduced NF-kappaB activity
Nozell et al., J Immunol 2006 (Astrocytoma) : Mechanism of IFN-beta mediated inhibition of IL-8 gene expression in astroglioma cells ... Previous studies have shown that IFN-beta can inhibit the expression of IL-8 , although the mechanism is unknown
Laver et al., J Interferon Cytokine Res 2008 : IFN-beta mediated inhibition of IL-8 expression requires the ISGF3 components Stat1, Stat2, and IRF-9 ... In this study, we dissect the role of each member of the IFN stimulated gene factor 3 ( ISGF3 ) signaling complex in contributing to IFN-beta inhibition of IL-8 gene expression ... We conclude, through use of cell lines deficient for ISGF3 components, that all three members of this complex, Stat1, Stat2, and IFN regulatory factor-9 (IRF-9), are required for IFN-beta mediated inhibition of IL-8 expression ... In contrast to positive signaling by ISGF3 to activate gene expression, we find that the transactivation domains of Stat1 and Stat2 are not essential to IFN-beta inhibition of IL-8
Marsh et al., J Neurosci 2009 (Infarction, Middle Cerebral Artery...) : TLR4 can induce both IFNbeta and interferon stimulated genes through its adapter molecule Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Sehgal et al., Proc Natl Acad Sci U S A 1987 : The enhancement of IFN-beta 2 gene expression by diC8, interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases
Kohase et al., Mol Cell Biol 1987 : Platelet derived growth factor and interleukin-1 also led to the increased expression of IFN-beta 2
Oliveira et al., Mol Cell Biol 1994 : Earlier we demonstrated that beta interferon ( IFN-beta ) can inhibit tumor necrosis factor (TNF) induced IL-8 gene expression at the transcriptional level, apparently by a novel mechanism
Singh et al., J Interferon Cytokine Res 1996 (Lung Neoplasms...) : Interferon-beta prevents the upregulation of interleukin-8 expression in human melanoma cells ... Treatment of melanoma cells with interferon ( IFN ) alpha, beta, or gamma did not affect the constitutive expression of IL-8 , but IFN-alpha and IFN-beta blocked the upregulation of IL-8 expression in cells treated with IL-1 beta or TNF-alpha subsequent to or simultaneously with the IFN
Cousens et al., Proc Natl Acad Sci U S A 1997 (Cytomegalovirus Infections...) : Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
Eloranta et al., Scand J Immunol 1997 : Priming the DC lines with tumour necrosis factor-alpha, interleukin-10 (IL-10) or IL-4 did not affect the IFN-alpha/beta response induced by HSV
Singh et al., Cancer Res 1998 (Melanoma) : Furthermore, we report that IFN-alpha and IFN-beta did not inhibit steady-state IL-8 production ... In summary, our data suggest that the up-regulation of IL-8 expression in melanoma cells is regulated at the transcriptional level and is rapidly and specifically inhibited by IFN-alpha or IFN-beta , independent of de novo protein synthesis, perhaps due to a transient modification of a preexisting factor ( s )