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CXCR4 — SRC
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2)
→
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database S1P3 pathway:
CXCR4 (CXCR4)
→
Src (SRC)
(modification, activates)
Walter et al., Arterioscler Thromb Vasc Biol 2007*
Evidence: mutant phenotype, assay
Text-mined interactions from Literome
Cabioglu et al., Cancer Res 2005
(Breast Neoplasms) :
We report a novel mechanism of HER2-neu transactivation through SDF-1alpha stimulation of
CXCR4 that
involves Src kinase activation
Yuan et al., Molecular cancer 2013
(Cerebellar Neoplasms...) :
Our findings demonstrate a novel mechanism of GF
receptor/PDGFR-Src mediated dysregulation of
CXCR4 signaling that promotes MB cell migration, which could potentially be exploited for therapeutic targeting in SHH MB