Gene interactions and pathways from curated databases and text-mining

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DEFA1 — IL8

Text-mined interactions from Literome

Feoktistov et al., Circ Res 2003 : A2B receptors mediate VEGF and IL-8 secretion because neither CGS21680 ( selective A2A agonist ) nor IB-MECA ( selective A3 agonist ) produced this effect, and it was inhibited by the selective A2B antagonist IPDX but not by the selective A2A antagonist SCH58261 or the selective A3 antagonist MRS1191
Phelps et al., Eur J Pharmacol 2006 (Urinary Bladder Neoplasms) : Lastly, NECA induced interleukin-8 secretion was inhibited by MRS 1754
Vieira et al., Am J Respir Crit Care Med 2011 (Airway Remodeling...) : Concerning the underlying mechanism, we observed that MRS2578 inhibited the release of IL-6 and IL-8/KC by lung epithelial cells in vivo, whereas intrapulmonary application of the P2Y6R agonist uridine-5'-diphosphate increased the bronchoalveolar levels of IL-6 and KC