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EPHB2 — EPX

Text-mined interactions from Literome

Mason et al., J Biol Chem 2000 : EPO dependent activation of ERK1/2 and protein kinase B (PKB)/Akt was examined utilizing a panel of EPO-R deletion mutants
Zhang et al., Exp Hematol 2001 : In contrast, EPO dependent p70 S6K phosphorylation/activation, as well as IRS-2 and ERK1/2 phosphorylation, were minimal or absent in cells transfected with EPO-R-131 or EPO-R-221
Arai et al., J Biol Chem 2001 : Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk, whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo induced phosphorylation of CrkL and activation of Erk
Chen et al., J Biol Chem 2001 : The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 blocked Myc up-regulation in a concentration dependent manner but had no effect on the Epo induced phosphorylation of ERK1 and ERK2
Kolonics et al., Haematologia (Budap) 2001 (Acute Disease...) : In UCBMNC and NBMMNC, Epo and GM-CSF induced the activation of STAT-5 DNA binding and ERK 1/2 activation ( n = 6 )
Lee et al., Biochem Biophys Res Commun 2004 : Conversely, treatment with anti-EPO and EPO receptor antibodies also reduced EPO induced ERK ( 2 ) and NF-kappaB activation
Bose et al., Am J Physiol Cell Physiol 2008 (Pancreatic Neoplasms) : Taken together, our results indicate that AR42J cells express EPOR and that the activation of both ERK1/2 and JNK1/2 by EPO is essential in regulating proliferation and the cell cycle
Talbot et al., PloS one 2011 (MAP Kinase Signaling System...) : This inhibition spares metabolic function but impedes EPO induced ERK signaling and disturbs a newly identified ERK-aconitase physical interaction
Dale et al., J Neurosci 2012 : EPO increased phosphorylation ( and presumed activation ) of ERK ( 1.6-fold vs controls ; p < 0.05 ) in phrenic motor neurons ; EPO also increased pAkt ( 1.6-fold vs controls ; p < 0.05 )
Jun et al., J Cell Physiol 2013 : In this study, we aimed to investigate the influence of EPO induced ERK signaling on the regulation of GATA-4 protein action ... EPO induced ERK activation further increased the association of GATA-4 with p300 ... Taken together, these results indicated that EPO induced ERK signaling activation increased GATA-4 phosphorylation and acetylation, partly via increase in the association between GATA-4 and p300, and these processes required the phosphorylation of GATA-4 at Ser-261 residue
Itoh et al., J Mol Cell Cardiol 2012 (Diabetes Mellitus, Type 2...) : Levels of calcineurin activity and EPO induced phosphorylation of Akt and ERK were similar in GK and Wistar, though cytosolic HSP70 level was 50 % lower and mitochondrial HSP60 level was 60 % higher in GK
Jun et al., Biol Pharm Bull 2013 : Under hypoxic condition without reperfusion, EPO induced ERK activation was associated with post-translational modification of GATA-4, mediated by enhancement of phosphorylation of GATA-4 at Ser-105
Barber et al., Blood 1997 : In addition, EPO , IL-2, and IL-15 activated Raf1 and ERK2 , demonstrating that the Raf1/MEK/MAP kinase pathway was activated