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NOTCH1 — RELN

Text-mined interactions from Literome

Keilani et al., BMC developmental biology 2008 : Reelin treatment increased the level of NICD, indicating that Reelin signaling directly activates Notch-1
Hashimoto-Torii et al., Neuron 2008 : Finally, our in vitro biochemical studies show that Reelin signaling inhibits Notch ICD degradation via Dab1
Keilani et al., Can J Physiol Pharmacol 2012 : We found that Reelin activated Notch-1 signaling, leading to the expression of brain lipid binding protein (BLBP) and the formation of radial glial cells in human neural progenitor cells ( hNPCs ) ... In the current study, we investigated the molecular mechanisms by which Reelin activates Notch-1 ... We show that Reelin stimulated Notch-1 activation is dependent on Reelin signaling ... The induction of Disabled-1 (Dab-1) tyrosine phosphorylation, and the subsequent activation of Src family kinases, were found to be essential steps for the activation of Notch-1 signaling by Reelin ... This study advances our knowledge of the regulation of Notch-1 activation by Reelin signaling in hNPCs, as an approach to understanding cell fate determination, differentiation, and neurogenesis during brain development