◀ Back to NOTCH1
DLL3 — NOTCH1
Pathways - manually collected, often from reviews:
-
KEGG Notch signaling pathway:
DLL1/DLL3/DLL4
→
NOTCH1/NOTCH2/NOTCH3/NOTCH4
(protein-protein, activation)
-
NCI Pathway Database Notch signaling pathway:
NOTCH1 heterodimer complex (NOTCH1)
→
Delta 3 (DLL3)
(modification, collaborate)
Shimizu et al., Biochem Biophys Res Commun 2000, Ladi et al., J Cell Biol 2005*, Nichols et al., J Cell Biol 2007, Blaumueller et al., Cell 1997, Luo et al., Mol Cell Biol 1997*
Evidence: assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
NOTCH1 heterodimer complex (NOTCH1)
→
Delta 3 (DLL3)
(modification, collaborate)
Shimizu et al., Biochem Biophys Res Commun 2000, Ladi et al., J Cell Biol 2005*, Nichols et al., J Cell Biol 2007, Heuss et al., Proc Natl Acad Sci U S A 2008*, Blaumueller et al., Cell 1997, Luo et al., Mol Cell Biol 1997*
Evidence: assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
NOTCH1 heterodimer complex (NOTCH1)
→
Delta 3 (DLL3)
(modification, collaborate)
Shimizu et al., Biochem Biophys Res Commun 2000, Ladi et al., J Cell Biol 2005*, Nichols et al., J Cell Biol 2007, Luo et al., Mol Cell Biol 1997*
Evidence: assay, physical interaction
-
WikiPathways NOTCH1 regulation of human endothelial cell calcification:
DLL1/DLL3/DLL4/JAG1/JAG2
→
NOTCH1
(activation)
-
WikiPathways Neural Crest Differentiation:
DLL3/DLL4/DLL1
→
NOTCH1/NOTCH4/NOTCH2/NOTCH3
(mim-binding)
-
WikiPathways Notch Signaling Pathway:
DLL1/DLL3/DLL4
→
NOTCH2/NOTCH3/NOTCH4/NOTCH1
(activation)
-
WikiPathways Canonical and Non-canonical Notch signaling:
JAG1/JAG2/DLL1/DLL3/DLL4/DLK1/DLK2/MFAP1/MFAP2/DNER/CNTN6
→
NOTCH1
(mim-binding)
Text-mined interactions from Literome
Ladi et al., J Cell Biol 2005
:
The divergent DSL ligand
Dll3 does not
activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
Geffers et al., J Cell Biol 2007
:
Dll3 does not compensate for Dll1
; DLL1 activates
Notch in Drosophila wing discs, but DLL3 does not
Mine et al., Oncol Rep 2010
(Fibrosarcoma...) :
Notch is
activated by
DLL and Jag presents on neighboring cells
Sugiyama et al., Biochem Biophys Res Commun 2010
:
Delta1 and Delta4, but not
Delta3 , exhibit filopodial protrusive activity, and this activity is
independent of
Notch signaling
Hoyne et al., Immunol Cell Biol 2011
:
We show that
Dll3 can not
activate Notch when expressed in trans but like other Notch ligands it can inhibit
Notch signalling when expressed in cis with the receptor
Turchi et al., Stem Cells 2013
:
Mechanistically, ERK dependent induction of miR-18a* directly represses expression of
DLL3 , an autocrine
inhibitor of
NOTCH , thus enhancing the level of activated NOTCH-1