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CASP3 — PIDD
Text-mined interactions from Literome
Tinel et al., Science 2004
:
Increased
PIDD expression
resulted in spontaneous activation of
caspase-2 and sensitization to apoptosis by genotoxic stimuli
Ren et al., Proc Natl Acad Sci U S A 2005
(Embryo Loss) :
This apoptosis is associated with up-regulation and nuclear localization of the tumor suppressor p53 and activation of mitochondrial apoptosis, which includes up-regulation of Bax, Bak, and
Pidd , translocation of Bax and caspase-2 onto mitochondria, release of cytochrome c and apoptosis inducing factor, and
activation of
caspase-9 and caspase-3
Manzl et al., J Cell Biol 2009
:
Because loss of either
PIDD or its adapter molecule RAIDD did not
affect subcellular localization, nuclear translocation, or
caspase-2 activation in high molecular weight complexes, we suggest that at least one alternative PIDDosome independent mechanism of caspase-2 activation exists in mammals in response to DNA damage