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IL13 — IL13RA2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: IL13RA2 — IL13 (direct interaction, biochemical) Caput et al., J Biol Chem 1996*
• IRef Dip Interaction: IL13RA2 — IL13 (direct interaction, x-ray crystallography) Lupardus et al., Structure 2010*
• IRef Dip Interaction: IL13RA2 — IL13 (direct interaction, isothermal titration calorimetry) Lupardus et al., Structure 2010*
• IRef Dip Interaction: IL13RA2 — IL13 (direct interaction, surface plasmon resonance) Lupardus et al., Structure 2010*
• IRef Dip Interaction: IL13RA2 — IL13 (direct interaction, molecular sieving) Lupardus et al., Structure 2010*
• IRef Hprd Interaction: IL13RA2 — IL13 (in vivo) Osawa et al., Immunogenetics 2000*
• IRef Hprd Interaction: IL13RA2 — IL13 (in vitro) Osawa et al., Immunogenetics 2000*
• IRef Innatedb Interaction: IL13RA2 — IL13 (unknown, -) Caput et al., J Biol Chem 1996*
• IRef Ophid Interaction: IL13RA2 — IL13 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Daines et al., J Biol Chem 2002 : Up-regulation of IL-13Ralpha2 surface expression in response to IFN-gamma was rapid, did not require protein synthesis, and resulted in diminished IL-13 signaling
Zheng et al., J Allergy Clin Immunol 2003 : In contrast, transgenic IL-13 caused a marked increase in IL-13Ralpha2 and IL-13Ralpha1 mRNA ; this was most prominent in airway epithelial cells and macrophages ... The effects of IL-13 on IL-13Ralpha2 were associated with comparable increases in protein production and were mediated by a blood leukocyte independent and IL-4Ralpha dependent mechanism
David et al., Oncogene 2003 : Finally, TNFalpha was shown to potentiate IL-4/IL-13 induced IL-13Ralpha2 promoter activity when the same reporter construct was studied in stably but not in transiently transfected cells ... These results suggest that the synergistic effect of TNFalpha on IL-4/IL-13 induced IL-13Ralpha2 expression is dependent upon chromatin re-modeling events
Yasunaga et al., Cytokine 2003 (Asthma...) : Either IL-4 or IL-13 induced intracellular expression of IL-13Ralpha2 in BECs, which was STAT6 dependent and required de novo protein synthesis ... IL-13Ralpha2 expressed on the cell surface as a monomer inhibited the STAT6 dependent IL-13 signal
Kawakami et al., Curr Gene Ther 2005 (Neoplasms) : In vivo intratumoral gene transfer of IL-13Ralpha2 profoundly enhanced the antitumor activity of IL13-PE , providing complete elimination of established tumor in some xenografts
Daines et al., J Immunol 2006 : IL-13Ralpha2 inhibited IL-13 signaling proportionally to its level of expression, and this inhibition could be overcome with high concentrations of IL-13
Andrews et al., J Allergy Clin Immunol 2006 : However, we found that the transmembrane form of IL-13Ralpha2 could attenuate both IL-13 and IL-4 responses, even though the response to TNF-alpha was unaffected
Badr et al., Egypt J Immunol 2006 (Melanoma...) : The release of soluble IL-13R alpha 2 was inhibited by various metalloproteinase inhibitors and EDTA inhibits the biological response to IL-13
Morimoto et al., J Immunol 2009 (Strongylida Infections) : An infection induced up-regulation of IL-13Ralpha2 gene expression was confined to smooth muscle and was dependent on STAT6 and IL-13 , but not on IL-4