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HSP90AA1 — SETD2

Text-mined interactions from Literome

Minet et al., FEBS Lett 1999 (Anoxia) : Hypoxia induced activation of HIF-1 : role of HIF-1alpha-Hsp90 interaction ... This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia ... At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin
Braliou et al., Biochem Biophys Res Commun 2006 : The use of this system for the identification and characterization of HIF-1 effectors was first validated by showing that two chemical Hsp90 inhibitors, geldanamycin and radicicol, impaired the activity of HIF-1 in yeast
Lee et al., Int J Cancer 2012 (Neoplasms...) : Thus, the inhibition of HIF-1a activity by hemin might result from its interaction with HSP90
Sahu et al., Mol Biol Cell 2012 (Neoplasm Invasiveness...) : Our finding that HIF-1a regulates secretion of heat shock protein-90a (Hsp90a) for cell migration raises the exciting possibility that targeting the secreted Hsp90a from HIF-1a positive tumors has a better clinical outlook
Schilling et al., PloS one 2012 (Anoxia...) : Herein, we describe the effects of the novel Hsp90 inhibitor NVP-AUY922 and 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ), as a control, on HIF-1a levels and radiosensitivity of lung carcinoma cells under normoxic and hypoxic conditions