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ABL1 — STAT3

Text-mined interactions from Literome

Spiekermann et al., Exp Hematol 2002 (Cell Transformation, Neoplastic...) : Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong activation of STAT3 and STAT5 by TEL-JAK2 and TEL-ABL , but not by BCR-ABL
Coppo et al., Oncogene 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells
Nakamura et al., Oncogene 2005 (Cell Transformation, Neoplastic...) : These results indicate that MEKK1 plays a key role in Bcr-Abl induced STAT3 activation and in ES cells ' capacity for LIF independent self-renewal, and may thus be involved in Bcr-Abl mediated leukemogenesis in stem cells
Coppo et al., Br J Haematol 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : BCR-ABL activates STAT3 via JAK and MEK pathways in human cells ... Using BCR-ABL mutants, it was shown that BCR-ABL tyrosine kinase activity and its Tyr177 residue were necessary for STAT3 Ser727 phosphorylation ... Inhibition of BCR-ABL with imatinib mesylate led to a dose dependent downregulation of total STAT3 protein and mRNA, suggesting that BCR-ABL is involved in the transcriptional regulation of STAT3
Coppo et al., Cell Signal 2009 : To better understand the behavior of BCR-ABL in pluripotent stem cells, we previously developed a murine embryonic stem ( ES ) cell model transformed by p210-BCR-ABL and reported that BCR-ABL activates STAT3 , a major protein involved in ES cells self-renewal, which leads specifically to inhibition of ES cells differentiation
Allen et al., Blood 2011 (Leukemia, Lymphocytic, Chronic, B-Cell) : Our data show that CLL cells expressing high levels of c-Abl also show elevated levels of phospho-STAT3 , and that STAT3 phosphorylation in CLL cells is dependent on c-Abl activity