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CASP4 — DYRK1A

Text-mined interactions from Literome

Seifert et al., FEBS J 2008 : Depletion of DYRK1A from human cells by short interfering RNA inhibits the basal phosphorylation of caspase 9 at an inhibitory site, Thr125. DYRK1A dependent phosphorylation of Thr125 is also blocked by harmine, confirming the use of this beta-carboline alkaloid as a potent inhibitor of DYRK1A in cells ... When co-expressed in cells, DYRK1A interacts with caspase 9, strongly induces Thr125 phosphorylation and inhibits caspase 9 auto processing
Seifert et al., Cell Signal 2009 : p38alpha- and DYRK1A dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress