◀ Back to BMP2

BMP2 — BMPR1B

Pathways - manually collected, often from reviews:

• KEGG Cytokine-cytokine receptor interaction: BMP2 → Complex of BMPR1B-BMPR2 (protein-protein, activation)
• NCI Pathway Database BMP receptor signaling: FS (FST) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: FS (FST) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: RGM family (RGMB/RGMA/HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR2 (homodimer) complex (BMPR2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BAMBI (BAMBI) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/SMAD6 complex (MAP3K7-SMAD6) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: GREM1 (GREM1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) → BMP2-4/GREM1 complex (BMP4_BMP2-GREM1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: USAG1 (SOSTDC1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) → BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → SMAD1 (SMAD1) (modification, collaborate) Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → GADD34/PP1CA complex (ZFYVE16-PPP1R15A-PPP1CA) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: GADD34/PP1CA complex (ZFYVE16-PPP1R15A-PPP1CA) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD7/SMURF1 complex (SMAD7-SMURF1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD1 (SMAD1) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: XIAP (XIAP) → BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) (modification, collaborate)
  Yamaguchi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: XIAP (XIAP) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Yamaguchi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Yamaguchi et al., EMBO J 1999
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/NOG complex (BMP4_BMP2-NOG) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/NOG complex (BMP4_BMP2-NOG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/NOG complex (BMP4_BMP2-NOG) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: NOG (NOG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/FETUA complex (BMP4_BMP2-AHSG) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/FETUA complex (BMP4_BMP2-AHSG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/FETUA complex (BMP4_BMP2-AHSG) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: FETUA (AHSG) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: CHRD (CHRD) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRD complex (BMP4_BMP2-CHRD) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRD complex (BMP4_BMP2-CHRD) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRD complex (BMP4_BMP2-CHRD) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → CHRDL1 (CHRDL1) (modification, collaborate) Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: CER1 (CER1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CER1 complex (BMP4_BMP2-CER1) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CER1 complex (BMP4_BMP2-CER1) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/CER1 complex (BMP4_BMP2-CER1) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4 (homodimer) complex (BMP4_BMP2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B) → BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → RGM family (RGMB/RGMA/HFE2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR2 (homodimer) complex (BMPR2) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BAMBI (BAMBI) (modification, collaborate) Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2) → BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B) (modification, collaborate)
  Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, physical interaction, other species
• Reactome Reaction: BMP2 → BMPR1B (indirect_complex) Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003, Murakami et al., Mol Biol Cell 2003, Shi et al., J Cell Sci 2007, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
• Reactome Reaction: BMP2 → BMPR1B (reaction) Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BMPR1B — BMP2 (direct interaction, pull down) Gilboa et al., Mol Biol Cell 2000
• IRef Hprd Interaction: BMPR1B — BMP2 (in vitro) Keller et al., Nature structural & molecular biology 2004*, Yamaji et al., Biochem Biophys Res Commun 1994*, Barbara et al., J Biol Chem 1999
• IRef Hprd Interaction: BMPR1B — BMP2 (in vivo) Keller et al., Nature structural & molecular biology 2004*, Yamaji et al., Biochem Biophys Res Commun 1994*, Barbara et al., J Biol Chem 1999
• IRef Intact Interaction: BMPR1B — BMP2 (direct interaction, surface plasmon resonance) Kotzsch et al., EMBO J 2009*
• IRef Ophid Interaction: BMPR1B — BMP2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Murali et al., Development 2005 : These studies provide direct genetic evidence that Bmpr1a and Bmpr1b play redundant roles during retinal development, and that different threshold levels of Bmp signaling regulate distinct developmental programs such as patterning, growth and differentiation of the retina
Yoon et al., Proc Natl Acad Sci U S A 2005 (Osteochondrodysplasias) : In summary, our study demonstrates that BMPR1A and BMPR1B are functionally redundant during early chondrogenesis and that BMP signaling is required for chondrocyte proliferation, survival, and differentiation in vivo
Miyoshi et al., Biol Reprod 2006 : Since overexpression of BMPR1A and BMPR1B , but not SMADs, significantly enhanced the BMP responses, these type I receptors were revealed to be limiting factors for BMP signaling in KGN cells
Inai et al., Dev Biol 2008 : Exogenous BMP-2 or constitutively active ( ca ) BMPR-1B ( ALK6 ) -virus treatments induced migration of the mesenchymal cells into the collagen gels, whereas noggin, an antagonist of BMPs, or dominant negative ( dn ) BMPR-1 B ( ALK6 ) -virus treatments reduced cell migration from the mesenchymal cell aggregates