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AGTR1 — CASP7
Text-mined interactions from Literome
Matsumoto et al., Shock 2003
(Necrosis) :
DNA fragmentation, Lactate dehydrogenase ( LDH ) release, and
caspase-3 activity were measured in cultured HAEC after exposure to hypoxia in the
presence or absence of an
AT1-RA ( candesartan, CS ) and/or an ACEI ( temocaprilat, TC )
Katunuma et al., FEBS Lett 2006
:
Epigallo-catechin-gallate showed the strongest inhibition
at 1 x 10 ( -7 ) M to these caspases, but cysteine cathepsins and
caspase-8 were not
inhibited
Kishi et al., Hypertension 2010
(Disease Models, Animal) :
Angiotensin II type 1 receptor activated
caspase-3 through ras/mitogen activated protein kinase/extracellular signal regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats ... These findings suggest that in SHRSP,
angiotensin II type 1 receptor activated
caspase-3 acting through the Ras/p38 MAPK/ERK pathway in the RVLM might be involved in sympathoexcitation, which in turn plays a crucial role in the pathogenesis of hypertension
Fauconnier et al., Proc Natl Acad Sci U S A 2011
(Myocardial Reperfusion Injury...) :
At 1 and 15 d after reperfusion,
caspase-8 activation
resulted in S-nitrosylation of the RyR2 and depletion of calstabin2 from the RyR2 complex, resulting in diastolic sarcoplasmic reticulum ( SR ) Ca ( 2+ ) leak
Chen et al., Chem Res Toxicol 2012
:
CA
at 1 µM
suppressed the 6-OHDA induced nuclear condensation, reactive oxygen species generation, and cleavage of
caspase 3 and PARP
Chai et al., Acta Biochim Biophys Sin (Shanghai) 2012
(Pre-Eclampsia) :
AT1-AA increased TNF secretion and
caspase-3 activities ... AT1 receptor blockade completely abrogated
AT1-AA induced TNF-a secretion,
caspase-3 activation, and cardiomyocyte apoptosis