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LEP — UCP2

Text-mined interactions from Literome

Viguerie-Bascands et al., Biochem Biophys Res Commun 1999 : Human recombinant leptin did not affect UCP2 mRNA expression
Masaki et al., Biochim Biophys Acta 1999 : These results indicate that UCP gene expressions during pregnancy are regulated tissue-dependently, and up-regulation of uterine UCP2 and UCP3 mRNA may be due to increased leptin levels
Scarpace et al., J Endocrinol 2000 : Leptin ( 0.9 mg/day for 3 days ) increased both UCP2 and UCP3 mRNA by 30 % in the innervated and, surprisingly, in the denervated BAT ... The present findings indicate that : sympathetic innervation is necessary to maintain basal levels of UCP3 mRNA ; beta ( 3 ) -adrenergic agonist stimulation induces UCP3 mRNA ; leptin induces UCP2 and UCP3 mRNA and this induction is not dependent on sympathetic innervation ; RA increases UCP1 but decreases UCP2 and UCP3 mRNA ; and methylprednisolone suppresses UCP1, UCP2, and UCP3 mRNA equally
Ceddia et al., Eur J Biochem 2000 : Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes
Commins et al., Am J Physiol Endocrinol Metab 2001 (Body Weight) : Leptin also increased UCP2 mRNA in WAT of both WT and UCP1-deficient mice but increased UCP2 and UCP3 mRNA only in BAT from UCP1-deficient mice
Brown et al., FEBS Lett 2002 : We investigated the effects of glucose and leptin on UCP-2 expression in isolated human islets
González-Yanes et al., Cell Mol Life Sci 2003 : Leptin differentially regulates the expression of key genes in the rat adipocyte, upregulating the expression of UCP-2 and inhibiting the expression and secretion of leptin by a mechanism that involves PKC activity
Ramsay et al., Domest Anim Endocrinol 2005 : Expression of UCP2 was induced by leptin ( 100 ng/mL ; P < 0.05 )
Luo et al., Mol Cell Biochem 2008 : Furthermore, at the level of 10 and 100 ng/ml leptin not only selectively increased the gene expression of PGC-1alpha, CPT1, Cyt c, UCP2 , and UCP3 ( P < 0.05 ), but also enhanced COX enzyme activity which related to mitochondrial FAO
Ho et al., Neurotox Res 2010 (Neuroblastoma) : We observed induction of UCP2 expression by leptin in neuronal cultures, and hypothesize that leptin may preserve neuronal survival via UCP2
Zhou et al., Proc Natl Acad Sci U S A 1997 (Diabetes Mellitus, Type 1...) : Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
Scarpace et al., J Endocrinol 1998 : Leptin increased LPL mRNA by 80 %, UCP1 mRNA twofold, and UCP3 mRNA levels by 62 % in BAT, and increased UCP2 mRNA levels twofold in EWAT ... The present study indicates that leptin increases the gene expression of UCP2 in EWAT and that of UCP1, UCP3 and LPL in BAT, whereas reduced food consumption but not leptin, decreases LPL expression in WAT