Gene interactions and pathways from curated databases and text-mining

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IL2RA — LEP

Text-mined interactions from Literome

Rodríguez et al., Clin Exp Immunol 2007 (Malnutrition...) : Moreover, leptin enhanced the expression of CD69 and CD25 on CD4 ( + ) and CD8 ( + ) cells after stimulation with PMA-ionomycin
Liu et al., J Immunol 2012 (Genetic Predisposition to Disease...) : Leptin also inhibits CD4 ( + ) CD25 ( + ) Foxp3 ( + ) regulatory T cells, which are known to contribute significantly to the mechanisms of peripheral immune tolerance