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Illenberger et al., J Biol Chem 2003
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Rac2 regulation of phospholipase C-beta 2 activity and mode of membrane interactions in intact cells ... Constitutively active Rac2 ( 12V ) stimulated the activity of both GFP-PLCbeta(2) and GFP-PLCbeta(2)Delta in live cells, and enhanced their membrane association as evidenced by the marked reduction in their fluorescence recovery rates
Bourdon et al., Methods Enzymol 2006
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This method is readily applied to quantify activation of PLC by receptors and G proteins, and we illustrate here the selective activation of PLC-beta2 by Rac but not by Rho GTPases and the selective activation of PLC-epsilon by Rho but not Rac GTPases
Gutman et al., J Biol Chem 2010
:
PLCbeta(2) activation by Rac2 , which leads to slow lateral diffusion and much faster exchange, recruits PLCbeta(2) to act locally on PtdInsP ( 2 ) at specific domains