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NGF — PARP1

Text-mined interactions from Literome

Lu et al., Exp Cell Res 2000 : We demonstrate that NGF and EGF induce Rap1 activation in PC12-Shb cells, while FGF-2 fails to do so ... However, PC12 cells expressing Shb with an inactivated SH2 domain do not respond to NGF stimulation with Rap1 activation ... These results suggest a role of Shb in NGF dependent Rap1 signaling and this pathway may be of significance for neurite outgrowth under certain conditions
York et al., Mol Cell Biol 2000 : In PC12 cells, NGF activates Ras and Rap1 to elicit the rapid and sustained activation of ERKs respectively
Wu et al., J Neurosci 2001 (MAP Kinase Signaling System) : We investigated a role for endogenous Rap1 , a small monomeric GTP binding protein of the Ras family, in nerve growth factor (NGF) signaling in PC12 cells ... Although both epidermal growth factor (EGF) and NGF caused transient activation of Ras, only NGF induced the activation of Rap1 ... Pretreatment of PC12 cells with brefeldin A ( BFA ), which disrupts the Golgi and endosomal compartments, had little effect on Ras activation but strongly inhibited NGF induced Rap1 activation and continuing MAPK activation ... We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK
Delcroix et al., Prog Brain Res 2004 (Nerve Degeneration) : We found that NGF induced a sustained activation of Rap1 , a small monomeric GTP binding protein of the Ras family, and that this activation occurred in early endosomes that contain key elements of Rap1/pErk1/2 pathway
Obara et al., J Cell Sci 2004 : In PC12 cells, Src phosphorylation on S17 participates in the activation of the small G protein Rap1 by both cAMP and NGF ... In these cells, Rap1 is required for cAMP/PKA signaling to ERKs and also for the sustained activation of ERKs by NGF ... The activation of Rap1 by both cAMP and NGF was blocked by PP2, an inhibitor of Src family kinases, and by a Src mutant incapable of being phosphorylated by PKA ( SrcS17A ), consistent with the requirement of PKA phosphorylation of Src at S17 in these actions
Stessin et al., J Biol Chem 2006 : Soluble adenylyl cyclase mediates nerve growth factor induced activation of Rap1 ... These inhibitors, along with sAC-specific small interfering RNA, reveal that sAC is uniquely responsible for the NGF elicited rise in cAMP and is essential for the NGF induced activation of the small G protein Rap1 in PC12 cells
Wu et al., Traffic 2007 (MAP Kinase Signaling System) : Moreover, NGF induced activation of Rap1 and sustained activation of MAPK1/2 were markedly suppressed
Ravni et al., Mol Pharmacol 2008 : PACAP signaling to neuritogenesis was also impaired by dominant negative Rap1 expression but was not affected by inhibition of protein kinase C ( PKC ), indicating a G-protein coupled receptor mediated differentiation pathway distinct from the one activated by receptor tyrosine kinase ligands such as nerve growth factor (NGF) , that involves both Rap1 and PKC
Jeon et al., Exp Mol Med 2010 : Contrary to RhoA, Rap1 was activated by NGF , and DN-Rap1 suppressed neurite outgrowth, suggesting that Rap1 is also essential for neurite outgrowth ... These results suggest that NGF activates Rap1 , which, in turn, up-regulates ARAP3 leading to RhoA inactivation and neurite outgrowth from PC12 cells