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IL6 — VAV1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Song et al., J Immunol 1999
:
Tyrosine phosphorylation of
Vav stimulates
IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase dependent pathway ...
Vav expression, but not expression of domain mutated Vav,
increased IL-6 secretion from nonimmortalized bone marrow derived mast cells upon FcepsilonRI engagement ... We conclude that
Vav phosphorylation
contributes to
IL-6 induction in mast cells
Hanazono et al., Acta Haematol 1996
:
Here we report that granulocyte/macrophage-colony- stimulating factor ( GM-CSF ),
interleukin-3 , and erythropoietin (Epo)
induce rapid and transient tyrosine phosphorylation of
Vav and that Vav is constitutively associated with the SH3 domain of Grb2/Ash in a human leukemia cell line UT-7
Lee et al., FEBS Lett 1997
:
We show that
interleukin-6 (IL-6) induces transient tyrosine phosphorylation of
Vav in a human myeloma cell line, U266 ... A membrane-distal part of the cytoplasmic region of gp130 is critical for association between Vav and gp130, and the
IL-6 induced tyrosine phosphorylation of
Vav
Fischer et al., Curr Biol 1998
:
Vav is a crucial regulator of TCR mediated Ca2+ flux, cytoskeletal reorganization and TCR clustering, and these are
required for T-cell maturation,
interleukin-2 production and cell cycle progression