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IL6 — RAB7B
Text-mined interactions from Literome
Wang et al., Blood 2007
:
Here we demonstrate that
Rab7b can negatively
regulate lipopolysaccharide (LPS) induced production of tumor necrosis factor (TNF)-alpha,
IL-6 , nitric oxide, and IFN-beta, and potentiate LPS induced activation of mitogen activated protein kinase, nuclear factor kappaB, and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4
Yao et al., J Immunol 2009
(Inflammation) :
Accordingly,
Rab7b can negatively
regulate TLR9 triggered production of TNF-alpha,
IL-6 , and IFN-beta in macrophages by impairing activation of MAPKs and NF-kappaB pathways