◀ Back to IL6
IL6 — PTK2B
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chauhan et al., Oncogene 1999
(Multiple Myeloma) :
Finally,
interleukin-6 (IL-6), a known survival factor for MM cells,
inhibits both activation of
RAFTK and apoptosis of MM.1S cells triggered by Dex
Chauhan et al., J Biol Chem 2000
(Multiple Myeloma) :
Our previous studies have shown that activation of a
related adhesion focal tyrosine kinase ( RAFTK ) ( also known as Pyk2 ) is required for dexamethasone ( Dex ) -induced apoptosis in multiple myeloma ( MM ) cells and that human
interleukin-6 (IL-6) , a known growth and survival factor for MM cells,
blocks both RAFTK activation and apoptosis induced by Dex ... We show that
IL-6 triggers selective activation of SHP2 and its association with
RAFTK in Dex treated MM cells