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KAT2B — MDM2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KAT2B — MDM2 (direct interaction, pull down) Jin et al., J Biol Chem 2002*
• IRef Biogrid Interaction: KAT2B — MDM2 (physical association, affinity chromatography technology) Jin et al., J Biol Chem 2002*
• IRef Biogrid Interaction: KAT2B — MDM2 (direct interaction, enzymatic study) Jin et al., J Biol Chem 2004*
• IRef Biogrid Interaction: KAT2B — MDM2 (physical association, affinity chromatography technology) Jin et al., J Biol Chem 2004*
• IRef Biogrid Interaction: KAT2B — MDM2 (direct interaction, enzymatic study) Jung et al., J Clin Invest 2010*
• IRef Biogrid Interaction: KAT2B — MDM2 (direct interaction, enzymatic study) Wang et al., J Biol Chem 2011*
• IRef Hprd Interaction: KAT2B — MDM2 (in vitro) Jin et al., J Biol Chem 2002*
• IRef Hprd Interaction: KAT2B — MDM2 (in vivo) Jin et al., J Biol Chem 2002*
• IRef Ophid Interaction: MDM2 — KAT2B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Jin et al., J Biol Chem 2002 : Consistent with the above results, MDM2 significantly repressed the activation of p53 transcriptional activity by PCAF without apparently affecting the level of p53
Jin et al., J Biol Chem 2004 : Our further study showed that MDM2 also regulates the stability of PCAF ... Restriction of PCAF in the nucleus by leptomycin B did not affect MDM2 mediated PCAF degradation ... Consistently, overexpression of MDM2 in p53 null cells caused the reduction of the protein level of PCAF , but not the mRNA level
Kass et al., Cell cycle (Georgetown, Tex.) 2009 : We found that PCAF interacts with both Mdm2 and Chk2 and that PCAF increases Chk2 ubiquitination and degradation