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NANOG — SIRT1

Text-mined interactions from Literome

Han et al., Cell stem cell 2008 : SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization ... Endogenous ROS triggered apoptosis of wild-type mES through mitochondrial translocation of p53 and BAX but inhibited Nanog expression of SIRT1 ( -/- ) mES, indicating that SIRT1 makes mES cells sensitive to ROS and inhibits p53 mediated suppression of Nanog expression
Calvanese et al., Proc Natl Acad Sci U S A 2010 : The longevity promoting NAD+ dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53 dependent expression of NANOG