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IGF1 — WT1
Text-mined interactions from Literome
Idelman et al., J Biol Chem 2003
(Bone Neoplasms...) :
In the presence of mutant p53,
WT1 can not
repress the
IGF-IR promoter
Bentov et al., Endocrinology 2003
:
In the present study, we demonstrated that
IGF-I reduced
WT1 expression in osteosarcoma derived Saos-2 cells in a time- and dose dependent manner
Werner et al., Mol Cell Biol 1995
(Wilms Tumor) :
To study whether
WT1 could
suppress the expression of the endogenous
IGF-I-R gene, WT1 negative G401 cells were stably transfected with a WT1 expression vector
Werner et al., Adv Exp Med Biol 1993
(Kidney Neoplasms...) :
Future studies will define whether other disease states in which the IGF-I-R gene is highly expressed are also associated with loss of negative
regulation of the
IGF-I-R promoter by
WT1 or other tumor suppressor gene products
Karnieli et al., J Biol Chem 1996
(Cell Transformation, Neoplastic...) :
Because
WT1 has been shown previously to bind and
repress the
insulin-like growth factor I ( IGF-I-R ) promoter, we investigated whether this promoter is, in addition, a target for the aberrant EWS/WT1 transcription factor ...
EWS/WT1 activated the
IGF-I-R promoter approximately 340 %, whereas a fusion protein containing a three-amino acid insert ( KTS ) between zinc fingers 3 and 4 had no effect