Gene interactions and pathways from curated databases and text-mining

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IL8 — ROCK2

Text-mined interactions from Literome

Mattaliano et al., Am J Physiol Cell Physiol 2010 : ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL induced IL-8 production ... In addition, OxLDL treatment stimulated ROCK2 catalytic activity, and ROCK2 inhibition attenuated NF-kappaB activation and IL-8 production resulting from OxLDL activation of LOX-1
Liang et al., Zhonghua Yi Xue Za Zhi 2011 (Arthritis, Rheumatoid) : Inhibition of RhoA and ROCK with a specific inhibitor inhibited the secretion of IL-8 , RANTES and MCP-2 in PG-induced RA FLS
Rafferty et al., Cell Immunol 2012 : Suppressing ROCK with the Y27632 inhibitor suppressed IL-1 stimulated Caco-2 cell CXCL8/IL-8 and IEC-6 cell CCL2/MCP-1 secretion and mRNA levels