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CASP5 — RAC1

Text-mined interactions from Literome

Deshpande et al., FASEB J 2000 : Expression of Rac1N17 blocked TNF induced activation of nuclear factor-kappa B (NF-kappaB), increased activity of caspase-3 , and markedly augmented endothelial cell susceptibility to TNF induced apoptosis
Schotte et al., J Biol Chem 2004 : Rac1 induced caspase-1 activation was mediated by its effect on LIM kinase-1, which is targeting the actin cytoskeleton ... Rac-1 and LIM kinase-1 dominant negative mutants were shown to inhibit caspase-1 activation induced by overexpression of Asc, which is a caspase-1 activating adaptor protein
Basak et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Most important, we observed a role of Rac1/PAK1 signaling in activation of caspase-1 , which is necessary for maturation of pro-IL-1beta
Cacicedo et al., Diabetes 2005 (Diabetic Retinopathy) : NAD ( P ) H oxidase appeared to be involved in these responses, since overexpression of dominant negative subunits of NAD ( P ) H oxidase, such as phox47 ( DN ), diminished oxidant stress, and phox67 ( DN ) and N-17 RAC1 ( DN ) prevented the increase in caspase-3 activity
Le et al., J Neurochem 2005 : Clostridium difficile toxin B ( ToxB ), a specific Rho family inhibitor, induced a selective caspase mediated degradation of Rac1 without affecting RhoA or Cdc42 protein levels
Helfer et al., Cancer Res 2006 : In particular, caspase-8 is required for the optimal activation of calpains, Rac , and lamellipodial assembly
Kuijk et al., Blood 2008 (Mevalonate Kinase Deficiency) : HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB dependent caspase-1 activation ... IL-1beta release is mediated by caspase-1, and simvastatin treatment resulted in increased caspase-1 activity in a Rac1/PI3K dependent manner
Torres et al., Mol Biol Cell 2010 (Neoplasm Metastasis) : Integrin ligation leads to Rab5 activation, association with integrins, and activation of Rac , in a caspase-8 dependent manner