Gysin et al., Cancer Res 2005
(MAP Kinase Signaling System...) :
Inhibition of p27Kip1 expression in Mia PaCa-2 cells restored the activity of cyclin/cdk2, phosphorylation of pRb, and E2F activity and partially relieved the effects of U0126 on pancreatic cancer cell cycle arrest
Shiyanov et al., Mol Biol Cell 1997
:
The reduction in the expression of these genes correlates with the p27Kip1 induced accumulation of the repressor complexes of the E2F family of factors ( E2Fs )